Nucleic acid multimers and amplified nucleic acid...

C - Chemistry – Metallurgy – 07 – H

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167/44, 195/1.12

C07H 21/00 (2006.01) C07H 19/06 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/532 (2006.01) G01N 33/543 (2006.01)

Patent

CA 1339351

Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonucleotide unit that is complementary to a single-stranded oligonucleotide sequence of interest, and (2) a multiplicity of second single-stranded oligonucleotide units that are complementary to a single-stranded labeled oligonucleotide. Amplified sandwich nucleic acid hybridizations and immunoassays using the multimers are exemplified.

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