C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2506058
The invention relates to nucleic acid probes and to broadrange primers that are useful in the identification of bacterial species and the diagnosis of bacterial infections. Especially, the invention relates to specific nucleic acid probes that originate from hyper-variable regions situated near the conserved sequences of topoisomerase genes of infection-causing bacteria. The invention also relates to broad-range primers originating from the conserved regions of topoisomerase genes. Especially, the primers originate from conserved regions of the genes encoding the gyrB and/or parE protein. In addition, the invention relates to the use of these nucleic acid probes and broadrange primers in the diagnosis of bacterial infections as well as to diagnostic methods in which these nucleic acid probes and broad-range primers are used.
L'invention concerne des sondes d'acide nucléique et des amorces à large spectre utiles pour identifier des espèces bactériennes et diagnostiquer des infections bactériennes. Elle concerne notamment des sondes d'acide nucléique spécifiques qui proviennent de régions hypervariables se situant à proximité de séquences conservées de gènes de la topoisomérase de bactéries infectieuses. L'invention concerne également des amorces à large spectre qui proviennent de régions conservées de gènes de la topoisomérase. Les sondes proviennent notamment de régions conservées des gènes codant pour la protéine gyrB et/ou parE. L'invention concerne en outre l'utilisation desdites sondes d'acide nucléique et amorces à large spectre pour diagnostiquer des infections bactériennes, et des procédés diagnostiques utilisant de telles sondes et amorces.
Jalava Jari
Nikkari Simo
Roth Stina
Freedman Gordon
Mobidiag Oy
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