Nucleic acid sequences controlling lung cell-specific gene...

Details Nucleic acid sequences controlling lung cell-specific gene... Nucleic acid sequences controlling lung cell-specific gene...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/785 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/861 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2188157

An oligonucleotide which includes at least one nucleic acid sequence which binds to at least one nuclear protein found in lung cells, such as TTF-1 protein. The oligonucleotide may be contained in a vector. The at least one nuclear protein provides for lung cell-specific expression of the vector upon binding of the at least one nucleic acid sequence to the at least one nuclear protein. Such vector may also include genes encoding therapeutic agents, and may be employed for delivering genes encoding therapeutic agents to lung cells.

Oligonucléotide incluant au moins une séquence d'acide nucléique se liant à au moins une protéine nucléaire, telle que la TTF-11, présente dans des cellules du poumon et pouvant être contenue dans un vecteur. Ladite (ou les) protéine(s) nucléaire(s) assure(nt) une expression du vecteur spécifique aux cellules pulmonaires lors de la fixation de la ou des séquence(s) d'acide nucléique à la ou aux protéine(s) nucléaire(s). Le susdit vecteur peut également comporter des gènes codant pour des agents thérapeutiques et servir au transfert de gènes codant pour lesdits agents vers les cellules des poumons.

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