Nucleic acid sequences for atp-binding cassette transporter

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2281887

The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter and observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.

La présente invention se rapporte à des séquences d'acides nucléiques et d'acides aminés d'un transporteur à cassette de fixation à l'adénosine triphosphate (ATP) et à des séquences de ce transporteur ayant subi des mutations et associées à la dégénérescence maculaire. L'invention concerne des procédés de détection d'agents modifiant un transporteur à cassette de fixation à l'ATP, qui consistent à combiner un transporteur à cassette de fixation à l'ATP, purifié, et au moins un agent suspecté de modifier le transporteur à cassette de fixation à l'ATP, et à observer une modification dans au moins une caractéristique associée audit transporteur à cassette de fixation à l'ATP. La présente invention se rapporte également à des procédés de détection de la dégénérescence maculaire.

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