Nucleic acid transfer phage

Details Nucleic acid transfer phage Nucleic acid transfer phage

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 35/66 (2006.01) A61K 48/00 (2006.01) C07K 7/08 (2006.01) C07K 14/005 (2006.01) C07K 14/01 (2006.01) C07K 14/16 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2331384

A substance (a gene, etc.) to be transported is packaged in a phage in the head of which a bifunctional protein having a nuclear transport activity and a cell adhesion activity is expressed. As the bifunctional protein, use can be made of TAT of HIV. The phage thus constructed is usable in gene therapy.

Selon cette invention, une substance (un gène, etc.) destinée à être transportée est encapsulée dans un phage dans la tête duquel est exprimée une protéine bifonctionnelle possédant une activité de transport nucléaire et une activité d'adhérence cellulaire. En tant que protéine bifonctionnelle on peut utiliser le gène tat du virus VIH. Le phage de cette construction peut s'utiliser en thérapie génique.

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