C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A61K 39/00 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2395208
A nucleic acid vaccine construct comprising an isolated polynucleotide which encodes a polypeptide comprising at least five consecutive amino acid residues from the VNTR monomer of Muc1 wherein one or more of said amino acids is a glycosylation site, characterised in that when said isolated polynucleotide is expressed in a mammalian cell, glycosylation of the resulting polypeptide is altered or prevented at at least one of said glycosylation sites.
Cette invention porte sur un produit de synthèse vaccinal à base d'acide nucléique comprenant un polynucléotide isolé codant un polypeptide comportant au moins cinq restes d'acides aminés successifs issus d'un monomère VNTR (à séquences répétées en tandem en nombre variable) de la cellule Muc1, un acide aminé ou plusieurs de ceux-ci constituant un site de glycosylation. Ce vaccin se caractérise par le fait que, lorsque le polynucléotide isolé est exprimé dans une cellule mammalienne, la glycosylation du polypeptide résultant est modifiée ou empêchée sur l'un au moins des sites de glycosylation.
Crowe James Scott
Ellis Jonathan Henry
Glaxo Group Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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