Nucleic acids and methods for the discrimination between...

Details Nucleic acids and methods for the discrimination between... Nucleic acids and methods for the discrimination between...

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) C07H 21/04 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2188317

This invention is in the area of molecular biology/virology and presents oligonucleotides with nucleotide-sequence specific for S1 HIV-1 strains. These oligonucleotides may be used for in vitro determination of biological phenotype of HIV-1 strains in biological material from HIV-infection individuals by a number of techniques such as Southern and Northern blot analysis, PCR, NASBA, in situ hybridization branched DNA hybridization on, heteroduplex tracing hybridization and liquid hybridizations. HIV-1 phenotyping may i.e. be used as a diagnostic marker for disease progression or for testing efficacy of antiviral therapy.

Dans le domaine de la virologie/biologie moléculaire, on a mis au point des oligonucléotides présentant des séquences nucléotidiques spécifiques des souches de VIH-1 induisant le syncytium. Ces oligonucléotides sont utilisables dans la détermination in vitro du phénotype biologique des souches de VIH-1 dans les matières biologiques prélevées chez les personnes infectées par le VIH, et ce à l'aide d'un certain nombre de techniques telles que l'analyse par transfert de Southern et de Northern, l'amplification PCR, le procédé NASBA, l'hybridation in situ, l'hybridation de l'ADN ramifié, l'hybridation par détection d'hétéroduplex, et les hybridations en phase liquide. Le phénotypage du VIH-1 est utilisable, par exemple, comme marqueur diagnostique de l'évolution d'une pathologie ou dans le contrôle de l'efficacité d'un traitement antiviral.

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