Nucleic acids and methods of use thereof for controlling...

Details Nucleic acids and methods of use thereof for controlling... Nucleic acids and methods of use thereof for controlling...

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C12N 5/10 (2006.01) C12N 9/22 (2006.01) C12N 15/11 (2006.01) C12N 15/33 (2006.01) C12N 15/82 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2137161

The invention consists of a non-naturally occurring nucleic acid molecule capable of blocking or interfering with a replica- tive intermediate of a virus, a virusoid, or a viroid. The nucleic acid molecule may contain a ribozyme or a plurality of ribozymes. Alternatively, the nucleic acid molecule may be an antisense nucleic acid molecule. The ribozyme may be a hairpin ribozyme, a hammerhead ribozyme, an RNAase P ribozyme, a minizyme, or other catalytic RNA molecule. The virus may be an animal, a mammalian, a plant, a fungal, a protozoan, a yeast, a bacterial virus, or a human virus. The nucleic acid molecule may be ex- pressed in the cell or it may be preformed and administered ex vivo. The present invention contemplates methods of controlling infection of a pathogenic infectious agent in a plant or animal.

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