Nucleic acids encoding a g-protein coupled receptor involved...

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/12 (2006.01) A61K 45/00 (2006.01) A61P 3/10 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2477348

The invention provides isolated nucleic acid and amino acid sequences of human and murine islet cell G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, methods of screening for modulators of islet cell G-protein coupled receptors and methods of treating mammals with modulators of islet cell G-protein coupled receptor activity.

L'invention concerne des séquences d'acides nucléiques et d'acides aminés isolées de récepteurs couplés à une protéine G (GPCR) de cellules d'îlots pancréatiques humaines et de souris, des anticorps de tels récepteurs, des méthodes de détection de tels acides nucléiques et de tels récepteurs, des méthodes de criblage de modulateurs de récepteurs couplés à une protéine G de cellules d'îlots pancréatiques, et des méthodes de traitement de mammifères faisant appel à des modulateurs de l'activité des récepteurs couplés à la protéine G de cellules d'îlots pancréatiques.

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