C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61L 27/00 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/58 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2408073
The present invention relates to nucleic acids that encode novel Regulator of G protein Signaling RGS18 polypeptides. RGS18 polypeptides are abundantly expressed in platelets and comprise a novel RGS domain (RGS18 domain). The present invention also relates to RGS18 polypeptides. The invention also relates to means for the detection of RGS18 nucleic acids and RGS18 polypeptides. The invention also relates to methods for the detection of activators or inhibitors of RGS18 polypeptides. Finally, the present invention relates to methods of prevention and/or treatment of disorders or conditions associated with platelet activation dysfunction.
L'invention concerne des acides nucléiques codant un nouveau régulateur des polypeptides RGS18 de signalisation de la protéine G. Ces polypeptides RGS18 sont abondamment exprimés dans les plaquettes et comprennent un nouveau domaine RGS (domaine RGS18). Elle concerne également des polypeptides RGS18. Elle concerne des moyens servant à détecter des acides nucléiques RGS18 et des polypeptides RGS18. Elle concerne des procédés servant à détecter des activateurs ou des inhibiteurs de ces polypeptides RGS18. Elle concerne enfin des procédés de prévention et/ou de traitement de maladies ou de troubles associés au dysfonctionnement de l'activation des plaquettes.
Gagnon Alison W.
Murray David L.
Aventis Pharmaceuticals Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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