Nucleic acids encoding cd40/cd40l chimeric polypeptides,...

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/62 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2369820

A nucleic acid encoding a chimeric polypeptide comprising nucleic acid fragments encoding i) a mammalian signal peptide and downstream thereof, ii) the binding and trimerization domain of CD40L and downstream thereof, iii) a spacer of 50 to 100 amino acids and downstream thereof, iv) the transmembrane and signal transduction domains of CD40, is useful as a gene therapy agent for the local treatment of solid tumors.

Cette invention concerne un acide nucléique codant pour un polypeptide chimère comprenant des fragments d'acide nucléique codant pour: i) un peptide signal mammifère et ce qui en découle; ii) le domaine de liaison et de trimérisation de CD40L et ce qui en découle; iii) un espaceur de 50 à 100 acides aminés et ce qui en découle; iv) les domaines transmembranaires et de transduction de signal de CD40. Cet acide nucléique est utile comme agent de thérapie génique pour le traitement local des tumeurs solides.

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