Nucleic acids encoding merosin, merosin fragments and uses...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2172385

This invention provides an isolated nucleic acid molecule encoding a subunit of a protein, the protein having an apparent molecular weight of about 800 kD, designated merosin. Also provided are isolated nucleic acid molecules which encode merosin fragments. Anti- merosin antibodies, vectors for the recombinant production of merosin, and the expression of recombinant proteins by use of a host vector system also are provided. The invention further provides the use of merosin to promote neurite growth and for certain diagnostic applications.

L'invention se rapporte à une molécule d'acide nucléique isolée qui code une sous-unité d'une protéine, à savoir la protéine ayant un poids moléculaire apparent d'environ 800 kD appelée mérosine. L'invention se rapporte également à des molécules d'acides nucléiques isolées qui codent des fragemnts de mérosine. Des anticorps contre la mérosine, des vecteurs pour la production par recombinaison de mérosine et l'expression de protéines recombinées au moyen d'un système de vecteurs hôtes sont également décrits. Cette invention concerne en outre l'utilisation de la mérosine pour promouvoir la croissance des neurites ainsi que son utilisation dans certaines applications diagnostiques.

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