Nucleic acids encoding modified cytochrome p450 enzymes and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/02 (2006.01) C07H 21/04 (2006.01) C12N 1/20 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2623687

The present invention provides nucleic acids comprising nucleotide sequences encoding modified cytochrome P450 enzymes; as well as recombinant vectors and host cells comprising the nucleic acids. The present invention further provides methods of producing a functionalized compound in a host cell genetically modified with a nucleic acid comprising nucleotide sequences encoding a modified cytochrome P450 enzyme.

L'invention concerne des acides nucléiques comprenant des séquences nucléotidiques codant des enzymes du cytochrome P450 modifiées. La présente invention porte également sur des vecteurs recombinants et des cellules hôtes contenant ces acides nucléiques ainsi que sur des procédés pour produire un composé fonctionnalisé dans une cellule hôte génétiquement modifiée avec un acide nucléique comportant des séquences nucléotidiques codant une enzyme du cytochrome P450 modifiée.

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