C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 39/215 (2006.01)
Patent
CA 2631382
The present invention relates to nucleic acids comprising: (a) sequences of a replication competent transmissible gasroenteritis virus (TGEV) , which sequences encode a TGEV replicase under the control of expression regulatory sequences, wherein the replicase is expressed in a host cell and will initiate replication of the nucleic acid and thus increase the number of nucleic acids in the cell; and (b) a sequence encoding at least one neutralizing epitope of ORF5 of porcine reproductive and respiratory syndrome virus (PRRSV) , which sequence includes a disulfide bridge forming residue; and (c) a sequence encoding at least one further polypeptide capable of increasing an immune response against PRRSV. The present invention further relates to vectors, virus particles and host cells comprising these nucleic acids as well as their use for the preparation of vaccines, specifically for the preparation of vaccines.
L'invention concerne des acides nucléiques renfermant (a) des séquences d'un virus de gastro-entérite transmissible réplicatif (TGEV) qui codent une réplicase TGEV sous le contrôle des séquences régulatrices d'expression, la réplicase s'exprimant dans une cellule hôte, initiant la réplication de l'acide nucléique et augmentant, ainsi, le nombre d'acides nucléiques dans la cellule. Lesdits acides nucléiques renferment, également, (b) une séquence codant au moins un épitope de neutralisation de ORF5 du virus du syndrome dysgénésique et respiratoire du porc (PRRSV), ladite séquence contenant un résidu formant un pont disulfure, et (c) une séquence codant au moins un autre polypeptide capable d'augmenter une réponse immunitaire contre PRRSV. Cette invention a aussi pour objet des vecteurs, des particules de virus et des cellules hôtes contenant ces acides nucléiques, ainsi que leur utilisation dans la préparation de vaccins.
Enjuanes Sanches Luis
Plana Duran Joan
Sola Gurpegui Isabel
Zuniga Lucas Sonia
Consejo Superior de Investigaciones Cientificas
Fort Dodge Veterinaria S.a.
Ridout & Maybee Llp
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