Nucleic acids for expressing a polynucleotide of interest in...

Details Nucleic acids for expressing a polynucleotide of interest in... Nucleic acids for expressing a polynucleotide of interest in...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) C12N 15/113 (2010.01) A61K 48/00 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2663045

The invention relates to regulatory polynucleotides derived (i) from rat and human AFP promoter sequences and (ii) from rat and human HIP/PAPI promoter sequences, which regulatory polynucleotides are useful for expressing nucleic acids of interest specifically in mammalian cancer cells, including mammalian cancer liver cells.

Polynucléotides régulateurs, dérivés (i) de séquences promoteurs d'AFP chez le rat et l'homme et (ii) de séquences promoteurs d'HIP/PAPI chez le rat et l'homme, utiles pour l'expression d'acides nucléiques spécifiques, particulièrement dans des cellules cancéreuses mammaliennes, y compris les cellules cancéreuses mammaliennes du foie.

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