C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A61K 39/39 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2710534
The present invention relates to nucleic acids of the general formula (I): (N u G l X m G n N v)a and derivatives thereof as an immunostimulating agent/adjuvant and to compositions containing same, optionally comprising an additional adjuvant. The present invention furthermore relates to a pharmaceutical composition or to a vaccine, each containing nucleic acids of formula (I) above and/or derivatives thereof as an immunostimulating agent, and optionally at least one additional pharmaceutically active component, e.g. an antigenic agent. The present invention relates likewise to the use of the pharmaceutical composition or of the vaccine for the treatment of cancer diseases, infectious diseases, allergies and autoimmune diseases etc. Likewise, the present invention includes the use of nucleic acids of the general formula (I): (N u G l X m G n N v)a and/or derivatives thereof for the preparation of a pharmaceutical composition for the treatment of such diseases.
La présente invention concerne des acides nucléiques de formule générale (I) : (NuGlXmGnNv)a et leurs dérivés sous forme d'immunostimulant/adjuvant et des compositions qui les contiennent, comprenant éventuellement un adjuvant additionnel. La présente invention concerne en outre une composition pharmaceutique ou un vaccin contenant chacun les acides nucléiques de formule (I) ci-dessus et/ou leurs dérivés sous forme d'immunostimulant et éventuellement au moins un composant additionnel pharmaceutiquement actif, par exemple un agent antigénique. La présente invention concerne de même l'utilisation de la composition pharmaceutique ou du vaccin pour traiter les cancers, les maladies infectieuses, les allergies et les maladies auto-immunes, etc. La présente invention comprend également l'utilisation d'acides nucléiques de formule générale (I) : (NuGlXmGnNv)a et/ou de leurs dérivés pour la préparation d'une composition pharmaceutique pour traiter ce type de maladies.
Hoerr Ingmar
Kramps Thomas
Probst Jochen
Voss Soehnke
Curevac Gmbh
Kirby Eades Gale Baker
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