C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/00 (2006.01) C07K 14/37 (2006.01) C07K 16/14 (2006.01)
Patent
CA 2327456
The present invention provides the nucleotide sequence of the M antigen gene of H. capsulatum, which is set forth in the Sequence Listing as SEQ ID NO:1, a nucleic acid having the nucleotide sequence complementary thereto, and nucleic acids having a nucleotide sequence which is substantially the same as the foregoing nucleotide sequences. The present invention also provides vectors and host expressions systems containing the foregoing nucleic acids, and isolated or recombinantly-produced antigens encoded by the foregoing nucleic acids. The present invention further provides antibodies generated against the foregoing antigens, and methods and kits for detecting a previous or current Histoplasma capsulatum infection in a subject, and for diagnosing histoplasmosis.
L'invention concerne la séquence de nucléotides du gène de l'antigène M de H. capsulatum désignée SEQ ID N0 :1 dans l'énoncé des séquences, un acide nucléique possédant la séquence de nucléotides complémentaire de cette première séquence, et des acides nucléiques possédant une séquence de nucléotides pratiquement semblable à ces dernières séquences de nucléotides. Elle concerne également des vecteurs et des systèmes d'expression d'hôtes contenant ces acides nucléiques, ainsi que des antigènes isolés ou produits par recombinaison et codés par ces acides nucléiques. Elle concerne, de plus, des anticorps générés contre ces antigènes, des procédés et des trousses servant à détecter une infection anté
Deepe George S. Jr.
Lott Timothy J.
Mayer Leonard W.
Reiss Errol
Zancope-Oliveira Rosely M.
Centers For Dise The Government Of The United States Of America As Represented By
Macrae & Co.
The University Of Cincinnati
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