C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C12N 9/10 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) H01S 5/022 (2006.01) H01S 5/024 (2006.01) H01S 5/0683 (2006.01)
Patent
CA 2454822
The present invention relates to isolated and/or purified rat apoptosis- specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.
L'invention concerne des acides nucléiques isolés et/ou purifiés de déoxyhypusine synthase (DHS) et de facteur-5A (eIF-5A) d'initiation eucaryote spécifiques de l'apoptose chez le rat, et des polypeptides. L'invention concerne également des méthodes permettant de moduler une apoptose à l'aide de DHS et de eIF-5A spécifique d'une apoptose, des oligonucléotides antisens et des vecteurs d'expression de DHS et de eIF-5A spécifique d'une apoptose utilisés dans lesdites méthodes.
Carlson John C.
Cliche Dominic
Kaup Marianne
Narayansingh Richard
Petrov Larry
Borden Ladner Gervais Llp
Senesco Technologies Inc.
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