Nucleic acids, proteins, and antibodies

Details Nucleic acids, proteins, and antibodies Nucleic acids, proteins, and antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2395889

The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

La présente invention concerne des nouvelles protéines, et notamment des molécules d'acides nucléiques isolées codant pour des nouveaux polypeptides. Elle concerne également des nouveaux polypeptides et des anticorps se liant à ces polypeptides. L'invention se rapporte en outre à des vecteurs, à des cellules hôtes et à des méthodes recombinantes et synthétiques destinées à produire des polynucléotides et/ou des polypeptides humains et des anticorps. De même, cette invention concerne des méthodes diagnostiques et thérapeutiques utiles pour diagnostiquer, traiter, prévenir et/ou pronostiquer des troubles liés à ces nouveaux polypeptides. Elle fait également référence à des méthodes de criblage destinées à identifier des agonistes et des antagonistes de ces polynucléotides et de ces polypeptides. La présente invention concerne enfin des méthodes et/ou des compositions permettant d'inhiber ou d'accentuer la production et la fonction desdits polypeptides.

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