Nucleic acids, proteins, and antibodies

Details Nucleic acids, proteins, and antibodies Nucleic acids, proteins, and antibodies

C - Chemistry, Metallurgy

12

N

C12N 9/00 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 1/20 (2006.01) C12N 9/64 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2392428

The present invention relates to novel liver related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "liver antigens", and the use of such liver antigens for detecting disorders of the liver, particularly the presence of cancer of liver and cancer metastases. More specifically, isolated liver associated nucleic acid molecules are provided encoding novel liver associated polypeptides. Novel liver polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human liver associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the liver, including cancer of liver tissues, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.

L'invention concerne des polynucléotides liés au foie et des polypeptides codés par ces polynucléotides, dénommés génériquement "antigènes associés au foie" dans l'invention, qui concerne également l'utilisation de ces antigènes pour déceler les troubles du foie, en particulier le cancer et les métastases cancéreuses. Plus précisément, l'invention concerne des molécules d'acides nucléiques isolées associées au foie, qui codent les polypeptides associés au foie, des polypeptides et des anticorps associés au foie qui se lient aux polypeptides considérés, ainsi que des vecteurs, des cellules hôtes, et des procédés de recombinaison et synthétiques pour l'élaboration de polynucléotides et/ou de polypeptides humains associés au foie. L'invention concerne en outre des procédés diagnostiques et thérapeutiques utiles pour le diagnostic, le traitement, la prévention et/ou le pronostic en liaison avec des troubles associés au foie, y compris le cancer des tissus du foie, et des procédés thérapeutiques pour le traitement de ces troubles. L'invention concerne par ailleurs des procédés de criblage permettant d'identifier des agonistes et des antagonistes vis-à-vis des polynucléotides et des polypeptides décrits. L'invention concerne enfin des procédés et/ou des compositions permettant d'inhiber la production et la fonction des polypeptides considérés.

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