Nucleic acids, proteins, and antibodies

Details Nucleic acids, proteins, and antibodies Nucleic acids, proteins, and antibodies

C - Chemistry, Metallurgy

07

K

C07K 2/00 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 1/20 (2006.01) C12N 5/00 (2006.01) C12N 9/00 (2006.01) C12N 9/64 (2006.01) C12N 15/00 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2392450

The present invention relates to novel bladder related polynucleotides, the polypeptides encoded by these polynucleotides herein collectively referred to as "bladder antigens", and antibodies that immunospecifically bind these polypeptides, and the use of such bladder polynucleotides, antigens, and antibodies for detecting, treating, preventing and/or prognosing disorders of the bladder system, including, but not limited to, the presence of bladder cancer and bladder metastases. More specifically, isolated bladder nucleic acid molecules are provided encoding novel bladder polypeptides. Novel bladder polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human bladder polynucleotides, polypeptides, and/or antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the bladder, including bladder cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The invention further relates to methods and/or compositions for inhibiting or promoting the production and/or function of the polypeptides of the invention.

La présente invention concerne de nouveaux polynucléotides liés à la vessie, les polypeptides codés par ces polynucléotides appelés ici collectivement "antigènes de la vessie", ainsi que des anticorps fixant de manière immunospécifique ces polypeptides, et l'utilisation de ces polynucléotide, antigènes et anticorps de la vessie pour détecter, traiter, prévenir et/ou pronostiquer des troubles du système vésical, notamment, de façon non exhaustive, la présence d'un cancer de la vessie et de métastases de la vessie. Plus spécifiquement, l'invention concerne des molécules d'acides nucléiques de la vessie isolées codant les nouveaux polypeptides de la vessie. L'invention a trait à de nouveaux polypeptides de la vessie ainsi qu'à des anticorps se fixant à ces polypeptides. L'invention a également trait à des vecteurs, des cellules hôtes ainsi que des méthodes de recombinaison et de synthèse permettant de produire des polynucléotides, des polypeptides et/ou des anticorps de la vessie. L'invention concerne aussi des méthodes diagnostiques et thérapeutiques utiles pour diagnostiquer, traiter, prévenir et/ou pronostiquer des troubles liés à la vessie, notamment le cancer de la vessie ainsi que des méthodes thérapeutiques de traitement de ces troubles. L'invention porte également sur des méthodes de criblage permettant d'identifier des agonistes et des antagonistes de polynucléotides et de polypeptides de l'invention. Enfin, l'invention concerne des méthodes et/ou des compositions permettant d'inhiber ou de stimuler la production et/ou la fonction des polypeptides de l'invention.

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