Nucleophilic material modified for improved biocompatibility

Details Nucleophilic material modified for improved biocompatibility Nucleophilic material modified for improved biocompatibility

C - Chemistry, Metallurgy

08

B

167/104, 260/212

C08B 3/12 (2006.01) A61M 1/16 (2006.01) C08B 37/12 (2006.01)

Patent

CA 1311471

-54- NUCLEOPHILIC MATERIAL MODIFIED FOR IMPROVED BIOCOMPATIBILITY ABSTRACT A nucleophilic material is modified by reaction with a material having activated carbonyl groups, employing a nucleophilic-acyl substitution reaction which creates a non-ether linkage while retaining a free carboxyl group. Nucleophilic groups so modified lose their capacity to covalently bind C3b protein components. The retained free carboxyl group favors the binding of protein factors H&I as well as cationic C3a and C5a anaphylatoxins. A nucleophilic material modified as above stated also has the desirable characteristic of binding Beta-2-microglobulin and other poorly dialyzed molecules in the 1000 to 20000 molecular weight range. 5985C

559977

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