Nucleophilic substitution process

Details Nucleophilic substitution process Nucleophilic substitution process

C - Chemistry, Metallurgy

07

C

260/321, 260/559

C07C 57/58 (2006.01) C07D 209/46 (2006.01) C07C 121/66 (1980.01)

Patent

CA 1177086

ABSTRACT OF THE DISCLOSURE Nitroaralkyl cyanides are prepared by reacting a nitroaromatic compound with an alpha,alpha- disubstituted acetonitrile in a substantially anhydrous aprotic solvent and in the presence of a base so that the nitrile undergoes a nucleophilic substitution on an unsubstituted ring carbon of the halonitroaromatic compound during which an alpha-substituent functions as a leaving group. The nitroaralkyl cyanides formed by the process can be readily converted into derivatives, such as pharmaceuticals.

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