Nucleophilic substitution process

Details Nucleophilic substitution process Nucleophilic substitution process

C - Chemistry, Metallurgy

07

D

260/321, 260/322

C07D 209/44 (2006.01) C07C 79/46 (1980.01) C07C 101/453 (1980.01)

Patent

CA 1177085

ABSTRACT OF THE DISCLOSURE Nitroarylacetic acid esters are prepared by reacting a nitroaromatic compound with an alpha,alpha-disubstituted acetic acid ester in a sub- stantially anhydrous aprotic solvent and in the presence of a base so that the ester undergoes a nucleophilic substitution on an unsubstituted ring carbon of the nitroaromatic compound during which an alpha-substituent functions as a leaving group. The nitroarylacetic acid esters formed by the process can be readily converted into derivatives, such as pharmaceuticals.

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