Nucleoside 5'-monophosphate mimics and their prodrugs

Details Nucleoside 5'-monophosphate mimics and their prodrugs Nucleoside 5'-monophosphate mimics and their prodrugs

C - Chemistry, Metallurgy

07

H

C07H 19/04 (2006.01) A61K 31/7052 (2006.01) A61K 31/7056 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07H 19/044 (2006.01) C07H 19/052 (2006.01) C07H 19/056 (2006.01)

Patent

CA 2477795

The present invention relates to novel nucleoside 5'-monophosphate mimics, which contain novel nucleoside bases and phosphate moiety mimics optionally having sugar-modifications. The nucleotide mimics of the present invention, in a form of a pharmaceutically acceptable salt, a pharmaceutically acceptable prodrug, or a pharmaceutical formulation, are useful as antiviral, antimicrobial, anticancer, and immunomodulatory agents. The present invention provides a method for the treatment of viral infections, microbial infections, and proliferative disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of the present invention optionally in combination with other pharmaceutically active agents.

L'invention concerne de nouveaux analogues de nucléoside 5'-monophospate, qui contiennent de nouvelles bases de nucléoside et des analogues de fractions de phosphate présentant des modifications de sucre. Lesdits analogues de nucléotides de l'invention, sous forme d'un sel pharmaceutiquement acceptable, d'un promédicament pharmaceutiquement acceptable ou d'une formulation pharmaceutique sont utilisés en tant qu'agents antiviraux, antimicrobiens, anticancéreux et immunomodulateurs. L'invention concerne également une méthode de traitement d'infections virales, d'infections microbiennes et de troubles proliférants. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés de l'invention éventuellement en combinaison avec d'autres agents actifs pharmaceutiquement.

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