Nucleoside analogues

Details Nucleoside analogues Nucleoside analogues

C - Chemistry, Metallurgy

07

H

C07H 19/044 (2006.01) C07D 207/34 (2006.01) C07D 209/16 (2006.01) C07D 403/04 (2006.01) C07D 409/04 (2006.01) C07D 517/04 (2006.01) C07F 9/6558 (2006.01) C07H 19/052 (2006.01) C07H 19/056 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2243679

Nucleoside analogues in which a group M replaces the natural base where M is (1) or (2) or (3), where each of X1, X2 and X3 are C or N, each of R6 and R7 is the same or different and each is H, NO2, CO, COR8, OR8, CN, O, CON(R8)2, COOR8, SO2R8, SO3R8, SR8, NHCHO, (CH2)n(R8)2, halogen, or a reporter moiety, each of R8 and R9 is H or hydrocarbyl or a reporter moiety, and n is 0-4. The analogues are substrates for polymerase and terminal transferase enzymes.

Analogues de nucléosides dans lesquels un groupe M remplace la base naturelle dans laquelle M représente (1), (2) ou (3) dans lesquelles chacun de X?1¿, X?2¿ et X?3¿ représente C ou N, chacun de R?6¿ et de R?7¿ est semblable ou différent et chacun représente H, NO¿2?, CO, COR?8¿, OR?8¿, CN, O, CON(R?8¿)¿2?, COOR?8¿, SO¿2?R?8¿, SO¿3?R?8¿, SR?8¿, NHCHO, (CH¿2?)¿n?N(R?8¿)¿2?, halogène ou une fraction de ligand, chacun de R?8¿ et de R?9¿ représente H ou hydrocarbyle ou une fraction de ligand, et n est 0-4. Ces analogues sont des substrats de polymérase et de transférase terminale.

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