C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/073 (2006.01) A61K 31/7068 (2006.01) A61K 31/7076 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07D 239/46 (2006.01) C07D 473/00 (2006.01) C07H 19/04 (2006.01) C07H 19/173 (2006.01)
Patent
CA 2712073
The present invention comprises compounds useful as antiviral or antitumor agents. The compounds comprise nucleotide analogues that comprise tetrahydrofuranyl or tetrahydrothienyl moeities with quaternary centers at the 3' position. The nucleotide analogues can be used to inhibit cancer or viruses. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting diseases or conditions associated with cancers and viruses. Thus, the present invention also comprising pharmaceutical formulations comprising the compounds and methods of using the compounds and formulations to inhibit viruses or tumors and treat, prevent, or inhibit the foregoing diseases.
La présente invention concerne des composés utiles comme agents antiviraux ou antitumoraux. Ces composés comprennent des analogues nucléotidiques renfermant des fractions tétrahydrofuranyle ou tétrahydrothiényle à centres quaternaires en position 3'. Ces analogues nucléotidiques peuvent être utilisés pour inhiber un cancer ou des virus. Par conséquent, les composés de la présente invention sont utiles pour traiter, prévenir et/ou inhiber des maladies ou des pathologies associées à des cancers et des virus. L'invention concerne également des préparations pharmaceutiques comprenant ces composés ainsi que des méthodes d'utilisation de ces composés et de ces préparations pour inhiber des virus ou des tumeurs et pour traiter, prévenir ou inhiber les maladies qui leur sont associées.
Goudreau Gage Dubuc
Institut de Recherches Cliniques de Montreal
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