Nucleoside compounds and uses thereof

Details Nucleoside compounds and uses thereof Nucleoside compounds and uses thereof

C - Chemistry, Metallurgy

07

H

C07H 19/052 (2006.01) A61K 31/70 (2006.01) C07H 19/056 (2006.01)

Patent

CA 2400370

Nucleoside analogs and their prodrug forms include a sugar moiety and a heterocyclic base moiety, wherein especially preferred sugar moieties include ribofuranose, and particularly preferred base moieties include diazole and triazole. Contemplated compounds may be employed in pharmaceutical compositions, which may be used to treat an infection, an infestation, a neoplasm, or an autoimmune disease. Further contemplated uses include immunomodulation, and particularly modulation of Type 1 and Type 2 cytokine expression.

La présente invention concerne des analogues nucléosidiques et leurs formes promédicamenteuses renfermant une fraction sucre et une fraction à base hétérocyclique. Les fractions sucre particulièrement préférées contiennent du ribofuranose et les fractions de base particulièrement préférées contiennent du diazole et du triazole. En outre, on peut utiliser les composés visés dans des compositions pharmaceutiques pouvant être utilisées pour traiter une infection, une infestation, un néoplasme, ou une maladie auto-immune. Ces composés peuvent avoir d'autres utilisations, notamment dans l'immunomodulation, et particulièrement la modulation de l'expression des cytokines de type 1 et de type 2.

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