C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/19 (2006.01) A61K 31/7068 (2006.01) A61K 31/7072 (2006.01) A61K 31/7076 (2006.01) A61P 31/14 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 19/16 (2006.01) C07H 19/167 (2006.01) C07H 19/20 (2006.01)
Patent
CA 2488534
The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA- dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
L'invention concerne des composés nucléosidiques et certains de leurs dérivés qui sont des inhibiteurs de l'ARN polymérase virale ARN-dépendante. Ces composés sont des inhibiteurs d'une réplication ARN virale de l'ARN polymérase virale ARN-dépendante et sont utiles pour le traitement d'une infection ARN virale ARN-dépendante. Ils sont notamment utiles en tant qu'inhibiteurs de la polymérase NS5B du virus de l'hépatite C (HCV), en tant qu'inhibiteurs de la réplication HCV et/ou pour le traitement d'une infection à l'hépatite C. L'invention concerne également des compositions pharmaceutiques contenant ces composés nucléosidiques seuls ou combinés à d'autres agents actifs contre une infection ARN virale ARN-dépendante, notamment une infection à HCV. L'invention concerne également des méthodes permettant d'inhiber une ARN polymérase ARN-dépendante, d'inhiber une réplication ARN virale ARN-dépendante et/ou de traiter une infection ARN virale ARN-dépendante au moyen des composés nucléosidiques selon l'invention.
Bhat Balkrishen
Carroll Steven S.
Dande Prasad
Durette Philippe L.
Eldrup Anne B.
Gowling Lafleur Henderson Llp
Isis Pharmaceuticals Inc.
Merck & Co. Inc.
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