Nucleoside derivatives as inhibitors of rna-dependent rna...

Details Nucleoside derivatives as inhibitors of rna-dependent rna... Nucleoside derivatives as inhibitors of rna-dependent rna...

C - Chemistry, Metallurgy

07

H

C07H 19/167 (2006.01) A61K 31/7076 (2006.01) A61P 31/14 (2006.01) C07H 19/14 (2006.01) C07H 19/16 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2488484

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA- dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

La présente invention concerne des composés nucléosidiques et certains de leurs dérivés qui sont des inhibiteurs de l'ARN polymérase ARN-dépendante virale. Ces composés sont des inhibiteurs de la réplication virale de l'ARN ARN-dépendante et sont utiles pour le traitement d'une infection virale ARN ARN-dépendante. Ces composés sont tout particulièrement utiles comme inhibiteurs de la polymérase NS5B du virus de l'hépatite C (VHC), comme inhibiteurs de la réplication du VHC, et/ou pour le traitement d'une infection par le virus de l'hépatite C. L'invention concerne également des compositions pharmaceutiques contenant ces composés nucléosidiques seuls ou combinés à d'autres agents actifs contre une infection virale ARN ARN-dépendante, en particulier une infection par le virus de l'hépatite C. L'invention concerne également des méthodes permettant d'inhiber l'ARN polymérase ARN-dépendante, d'inhiber la réplication virale de l'ARN ARN-dépendante, et/ou de traiter une infection virale ARN ARN-dépendante, utilisant les composés nucléosidiques de la présente invention.

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