C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/04 (2006.01) A61K 31/706 (2006.01) A61P 31/14 (2006.01) C07H 7/06 (2006.01) C07H 19/06 (2006.01) C07H 19/14 (2006.01) C07H 19/16 (2006.01)
Patent
CA 2433878
The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA- dependent RNA viral replication and are useful for the treatment of RNA- dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.
Cette invention concerne des dérivés de nucléoside, qui sont des inhibiteurs de l'ARN polymérase virale ARN-dépendante. Ces composés sont des inhibiteurs de l'ARN réplication virale ARN-dépendante, et sont utiles dans le traitement d'ARN infections virales ARN-dépendantes. Ces composés sont particulièrement utiles en tant qu'inhibiteurs de la polymérase NS5B du virus de l'hépatite C (VHC), en tant qu'inhibiteurs de la réplication du VHC, et/ou pour le traitement de l'infection de l'hépatite C. La présente invention concerne également des compositions pharmaceutiques contenant de tels dérivés de nucléoside seuls ou en combinaison avec d'autres agents agissant contre les ARN infections virales ARN-dépendantes, en particulier l'infection du VHC. Cette invention concerne également des méthodes permettant d'inhiber l'ARN polymérase ARN-dépendante, d'inhiber les ARN réplications virales ARN-dépendantes et/ou de traiter des ARN infections virales ARN-dépendantes au moyen des dérivés de nucléoside ci-décrits.
An Haoyun
Bhat Balkrishen
Bhat Neelima
Carroll Steven S.
Cook Phillip Dan
Gowling Lafleur Henderson Llp
Isis Pharmaceuticals Inc.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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