C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/10 (2006.01) A61K 31/70 (2006.01) C07H 19/06 (2006.01) C07H 19/20 (2006.01)
Patent
CA 2382467
Novel compounds are provided in the form of nucleoside pyrophosphate and triphosphate analogs. In these analogs, the pyrophosphate or triphosphate group is replaced with a moiety that is isosterically and electronically identical thereto, but is hydrolytically and enzymatically more stable. The compounds are useful as therapeutic agents, e.g., as antiviral agents, anticancer agents, metabolic moderators and the like. The invention also provides pharmaceutical compositions containing a compound of the invention as an active agent, and in addition provides methods of treating disease, including viral infections, cancer, bacterial infections, inflammatory and/or autoimmune diseases, and the like, by administering a compound of the invention to a patient in need of such treatment.
L'invention concerne de nouveaux composés se présentant sous la forme d'analogues de pyrophosphates et de triphosphates nucléosidiques. Dans ces analogues, le groupe pyrophosphate ou triphosphate est remplacé par une fraction isostériquement ou électroniquement identique à celui-ci, mais plus stable du point de vue hydraulitique et enzymatique. Les composés sont utiles en tant qu'agents thérapeutiques, par exemple, en tant qu'agents antiviraux, agents anticancéreux, modérateurs métaboliques et analogues. L'invention concerne également des compositions pharmaceutiques contenant un composé de l'invention en tant qu'agent actif, et aussi des méthodes de traitement de maladies, notamment des infections virales, le cancer, des infections bactériennes, des maladies inflammatoires et/ou auto-immunes et analogues, par administration d'un composé de l'invention à un patient nécessitant un tel traitement.
Bottaro Jeffrey C.
Penwell Paul E.
Petrie Mark A.
Schmitt Robert J.
Battison Williams Dupuis
Sri International
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