Nucleosides analogues, such as antivirals including...

Details Nucleosides analogues, such as antivirals including... Nucleosides analogues, such as antivirals including...

C - Chemistry, Metallurgy

07

D

C07D 473/00 (2006.01) A61K 31/52 (2006.01) A61K 31/7076 (2006.01) C07D 213/80 (2006.01) C07D 213/85 (2006.01) C07D 307/68 (2006.01) C07D 473/18 (2006.01) C07D 473/32 (2006.01) C07D 513/04 (2006.01) C07H 17/08 (2006.01) C07H 19/04 (2006.01) C07H 19/16 (2006.01) C07H 19/167 (2006.01) C07H 19/173 (2006.01) C07B 61/00 (2006.01) C07H 19/16 (2006.01)

Patent

CA 2298704

A compound of the formula (I), wherein: nuc is the residue of a nucleoside analogue bonded through its single hydroxy group on the cyclic or acyclic saccharide moiety, R1 is hydroxy, amino or carboxy; optionally having esterified/amide bonded thereon; a C4-C22 saturated or unsaturated, optionally substituted fatty acid or alcohol, or an aliphatic L-amino acid; R2 is the residue of an aliphatic L-amino acid; L1 is a trifunctional linker group; L2 is absent or a difunctional linker group; and pharmaceutically acceptable salts thereof have favourable pharmacological properties and are antivirally active.

L'invention concerne un composé de la formule (I) dans laquelle: nuc est le résidu d'un analogue de nucléoside lié par son groupe hydroxy unique à la fraction de saccharide cyclique ou acyclique, R1 est hydroxy, amino ou carboxy; comportant éventuellement une liaison amide/estérifiée; un acide gras ou un alcool éventuellement substitué, saturé ou insaturé en C4-C22 ou un acide aminé L aliphatique; R2 est le résidu d'un acide aminé L aliphatique; L1 est un groupe de liaison trifonctionnel; L2 est absent ou est un groupe de liaison bifonctionnel; l'invention concerne également des sels de ce composé acceptables du point de vue pharmaceutique, et possédant des propriétés pharmacologiques bénéfiques ainsi qu'une activité antivirale.

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