Nucleosides of 5-monofluoromethyluracil and 5-...

Details Nucleosides of 5-monofluoromethyluracil and 5-... Nucleosides of 5-monofluoromethyluracil and 5-...

C - Chemistry, Metallurgy

07

H

260/210, 260/229

C07H 19/06 (2006.01) A61K 31/70 (2006.01) C07H 23/00 (2006.01)

Patent

CA 1292468

ABSTRACT ? method for synthesizing monofluoromethyl- and difluoromethyl- uracil nucleosides from the corresponding thymine nucleosides is developed. These compounds which contain a partially fluorinated methyl group at the C-5 position (a new class of nucleosides) are potential antiviral and/ox anticancer agents. The major features of the preparative route involve bromination of suitably protected thymine nucleosides followed by fluoride treatment.

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