Nucleosides with anti-hepatitis b virus activity

Details Nucleosides with anti-hepatitis b virus activity Nucleosides with anti-hepatitis b virus activity

A - Human Necessities

61

K

A61K 31/7068 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/522 (2006.01) A61K 31/7056 (2006.01) A61K 31/7072 (2006.01) A61P 31/20 (2006.01)

Patent

CA 2637774

A method for the treatment of a host, and in particular, a human, infected with HBV is provided that includes administering an HBV-treatment amount of a nucleoside of formula (I), (II) or (III), wherein R1 is hydrogen, fluoro, bromo, chloro, iodo, methyl or ethyl; and R2 is OH, Cl, NH2, or H; or a pharmaceutically acceptable salt of the compound, optionally in a pharmaceutically acceptable carrier or diluent.

L'invention porte sur une méthode de traitement d'un hôte, en particulier l'humain, infecté par le VHB. Le traitement comprend l'administration d'un traitement anti-VHB constitué d'une certaine quantité d'un nucléoside présentant la formule (I), (II) ou (III), où R1 est un hydrogène, un fluor, un brome, un chlore, un iode, un groupe méthyle ou éthyle; et R2 est un OH, un Cl, un NH2 ou un H; ou un sel pharmaceutiquement acceptable du composé, facultativement dans un diluant ou un vecteur pharmaceutiquement acceptable.

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