Nucleosides with anti-hepatitis b virus activity

Details Nucleosides with anti-hepatitis b virus activity Nucleosides with anti-hepatitis b virus activity

A - Human Necessities

61

K

A61K 31/7076 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/513 (2006.01) A61K 38/21 (2006.01) A61P 1/16 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2171550

A method for the treatment of a host, and in particular, a human, infected with HBV is provided that includes administering an HBV-treatment amount of a nucleoside of formula (I), (II) or (III), wherein R1 is hydrogen, fluoro, bromo, chloro, iodo, methyl or ethyl; and R2 is OH, Cl, NH2, or H; or a pharmaceutically acceptable salt of the compound, optionally in a pharmaceutically acceptable carrier or diluent.

Procédé de traitement d'un hôte, en particulier d'un homme, infecté par le virus de l'hépatite B(VHB), qui consiste à administrer une dose efficace de traitement anti-VHB d'un nucléoside des formules (I), (II) ou (III) dans lesquelles R<1> représente hydrogène, fluoro, bromo, chloro, iodo, méthyle ou éthyle et R<2> représente OH, Cl, NH2 ou H, ou d'un sel pharmaceutiquement acceptable dudit composé, éventuellement dans un excipient ou diluant pharmaceutiquement acceptable.

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