C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/6574 (2006.01) A61K 31/675 (2006.01) C07F 9/6571 (2006.01)
Patent
CA 2239020
Nucleotide phosphonate esters characterized by the presence of an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise an ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
La présente invention concerne des phosphonates esters de nucléotides caractérisés par la présence d'un groupe à liaison ester lié à l'atome phosphore d'analogues de nucléotides de phosphonates. Ces analogues comportent une liaison ester qui s'hydrolyse in vivo donnant ainsi un analogue correspondant de nucléotide de phosphonate. L'invention concerne également des procédés et des intermédiaires s'appliquant à leur synthèse et leur utilisation.
Arimilli Murty N.
Bischofberger Norbert W.
Jones Robert J.
Lee William A.
Prisbe Ernest J.
Gilead Sciences Inc.
Robic
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