Nucleotide analogs

Details Nucleotide analogs Nucleotide analogs

C - Chemistry, Metallurgy

07

H

C07H 19/20 (2006.01) A61K 31/662 (2006.01) A61K 38/02 (2006.01) A61P 31/12 (2006.01) C07F 9/6564 (2006.01) C07F 9/6571 (2006.01) C07F 9/6578 (2006.01) C07H 19/00 (2006.01) C07H 19/10 (2006.01) C07K 2/00 (2006.01)

Patent

CA 2171743

Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolysed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for the synthesis and use are described.

Analogues de nucléotides caractérisés par la présence d'un acide aminé lié à un amidate ou d'un groupe lié à un ester, qui est lié à l'atome de phosphore d'analogues de nucléotides phosphoniques. Les analogues comprennent une liaison phosphoamidate ou ester qui est hydrolysée in vivo pour produire un analogue de nucléotide phosphonique correspondant. Des procédés et des intermédiaires permettant la synthèse et l'utilisation de ces analogues sont également décrits.

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