Nucleotide analogues and their use for nucleic acid sequencing

Details Nucleotide analogues and their use for nucleic acid sequencing Nucleotide analogues and their use for nucleic acid sequencing

C - Chemistry, Metallurgy

07

H

C07H 19/00 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07K 1/107 (2006.01) C07K 1/13 (2006.01) C09B 1/36 (2006.01) C09B 11/08 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2468432

The invention relates to nucleosides comprising a reporter moiety which also functions to limit polymerase activity, characterised in that the reporter moiety is attached to the nucleoside through a linkage group cleavable by a hydrolase enzyme wherein the hydrolase enzyme is selected from the group consisting of esterases, phosphatases, peptidases, penicillin amidases, glycosidases and phosphorylases.

L'invention se rapporte à des nucléosides comprenant un fragment reporter servant à limiter l'activité de la polymérase. Le fragment reporter se caractérise en ce qu'il est fixé au nucléoside par un groupe de liaison clivable par une enzyme hydrolase. L'enzyme hydrolase est sélectionnée dans le groupe comprenant des estérases, des phosphatases, des peptidases, des amidases de pénicilline, des glycosidases et des phosphorylases.

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