Nucleotide analogues for topical treatment of proliferative...

Details Nucleotide analogues for topical treatment of proliferative... Nucleotide analogues for topical treatment of proliferative...

C - Chemistry, Metallurgy

07

H

C07H 19/10 (2006.01) A61K 31/52 (2006.01) A61K 31/661 (2006.01) A61K 31/6615 (2006.01) A61K 31/675 (2006.01) A61K 31/70 (2006.01) A61K 31/706 (2006.01) A61K 31/7064 (2006.01) A61K 31/7068 (2006.01) A61K 31/7072 (2006.01) A61K 31/7076 (2006.01) A61K 31/708 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 35/00 (2006.01) C07H 19/12 (2006.01) C07H 19/14 (2006.01) C07H 19/20 (2006.01) C07H 19/23 (2006.01)

Patent

CA 2222224

Pharmaceutical compositions containing mono-, di-, and triphosphate esters of antiproliferative nucleoside analogues, DNA chain-terminating dideoxynucleoside analogues and other nucleoside analogues for the topical treatment of hyperproliferative diseases of the skin, including psoriasis. The useful phosphate esters of the nucleoside analogues include phosphoramidates and phosphothiorates, as well as polyphosphates having C and S bridging atoms.

Les compositions pharmaceutiques décrites contiennent des esters de monophosphate, de diphosphate et de triphosphate d'analogues de nucléosides antiprolifératifs, des analogues de didésoxynucléosides de fin de chaîne d'ADN et d'autres analogues de nucléosides, et sont utiles pour le traitement topique de maladies hyperprolifératives de la peau, y compris le psoriasis. Les esters de phosphate utiles des analogues de nucléosides comprennent les phosphoramidates et les phosphothiorates, ainsi que les polyphosphates possédant des atomes de pontage C et S.

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