C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/06 (2006.01) A61K 31/7064 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07D 233/28 (2006.01) C07D 239/47 (2006.01) C07D 239/54 (2006.01) C07D 253/075 (2006.01) C07D 473/00 (2006.01) C07D 487/04 (2006.01) C07D 493/04 (2006.01) C07D 495/04 (2006.01) C07D 519/00 (2006.01) C07H 19/04 (2006.01) C07H 19/052 (2006.01) C07H 19/16 (2006.01)
Patent
CA 2755235
The present invention comprises compounds useful as antiviral or antitumor agents. The compounds comprise nu-cleotide analogues that comprise tetrahydrofuranyl or tetrahydrothienyl moeities with quaternary centers at the 3' position. The nu-cleotide analogues can be used to inhibit cancer or viruses. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting diseases or conditions associated with cancers and viruses. Thus, the present invention also comprising pharmaceutical formulations comprising the compounds and methods of using the compounds and formulations to in-hibit viruses or tumors and treat, prevent, or inhibit the foregoing diseases.
La présente invention comprend des composés utiles en tant quagents antiviraux ou antitumoraux. Les composés incluent des analogues de nucléotides qui comprennent des fonctions tétrahydrofuranyle ou tétrahydrothiényle comportant des centres quaternaires en position 3. Les analogues de nucléotides peuvent être utilisés pour inhiber un cancer ou des virus. Les composés de la présente invention sont ainsi utiles pour le traitement, la prévention et/ou linhibition de maladies ou de troubles associés avec les cancers et les virus. La présente invention comprend ainsi également des formulations pharmaceutiques qui comprennent les composés et des procédés dutilisation des composés et des formulations pour inhiber des virus ou des tumeurs et traiter, prévenir ou inhiber les maladies susmentionnées.
Goudreau Gage Dubuc
Institut de Recherches Cliniques de Montreal
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