Nucleotide and cellular vaccine composition

A - Human Necessities – 61 – K

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Details

A61K 48/00 (2006.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2522456

The present invention refers to a novel combination of nucleotide and cellular vaccine composition and pharmaceutical composition and use thereof for treating and/or preventing diseases, including infectious diseases, cancer, autoimmune diseases, allergy, diabetes and blood disorders. The vaccine composition comprises a nucleotide sequence encoding an antigenic molecule and gene-modified antigen-presenting cells (APCs), preferably provided as an intermixture. The APCs are modified to express immune modulating molecules. Immunization with the vaccine composition of present invention into a subject, induces the host immune system to respond and generate efficient immunity against either pre-existing disease or protect the host against the disease.

La présente invention porte sur une nouvelle combinaison d'une composition nucléotidique et cellulaire de vaccin et sur une composition pharmaceutique et son utilisation dans le traitement et/ou la prévention de maladies telles que des maladies infectieuses, du cancer, des maladies auto-immunes, des allergies, du diabète et des troubles sanguins. La composition de vaccin comprend une séquence nucléotidique codant une molécule antigénique et des cellules présentant un antigène modifié par un gène (APC), de préférence obtenues sous forme d'un entremêlement. Les APC sont modifiées pour exprimer des molécules immunes de modulation. L'immunisation avec la composition de vaccin de l'invention chez un sujet induit le système immun de l'hôte afin de réagir et générer une immunité efficace contre une maladie préexistante ou de protéger l'hôte d'une maladie.

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