C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2696634
The present invention is directed to monoclonal, chimeric or humanized, antibodies or antibody-like molecules that recognize an epitope common to human acidic and basic isoferritins. The anti- ferritin antibodies or antibody-like molecules can be used in pharmaceutical compositions for immunotherapy or radioimmunotherapy to target various cancer cells in a mammal. A method for delivering anti-ferritin antibodies or antibody-like molecules to cancerous lymph cells, pancreatic cells, lymphatic endothelium cells, and liver cells is also disclosed, as well as methods for treating pancreatic cancer, hepatocellular carcinomas, Kaposi's sarcoma and Hodgkin's lymphoma.
La présente invention porte sur des anticorps ou des molécules de type anticorps monoclonaux, chimériques ou humanisés qui reconnaissent un épitope commun aux isoferritines acides et basiques humaines. Les anticorps ou molécules de type anticorps anti-ferritines peuvent être utilisés dans des compositions pharmaceutiques utilisées pendant une immunothérapie ou une radio-immunothérapie pour cibler diverses cellules cancéreuses chez un mammifère. L'invention porte également sur un procédé d'administration d'anticorps ou de molécules de type anticorps anti-ferritines à des cellules lymphatiques, des cellules pancréatiques, des cellules endothéliales lymphatiques et des cellules hépatiques cancéreuses, ainsi que sur des procédés pour le traitement du cancer du pancréas, des carcinomes hépatocellulaires, du sarcome de Kaposi et du lymphome de Hodgkin.
Chose Olivier
Kadouche Jean
Sabbah-Petrover Emmanuelle
Goudreau Gage Dubuc
Monoclonal Antibodies Therapeutics
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