Nucleotide compound preparation and method for producing the...

Details Nucleotide compound preparation and method for producing the... Nucleotide compound preparation and method for producing the...

C - Chemistry, Metallurgy

07

H

260/229.1, 195/1

C07H 21/00 (2006.01) C07H 19/04 (2006.01)

Patent

CA 1214735

ABSTRACT OF THE DISCLOSURE A freeze-dried preparation of a protected nucleo- tide compound represented by the formula below, and a method for preparing the same, which comprises freeze drying a solution of an impure preparation whose solvent comprises dioxane Image [I] , wherein: R is hydrogen or a protected hydroxyl group; R1 is a chemical protecting group for phos- phate group; R2 is a chemical protecting group for hydroxyl group; B' is a protected base selected from guanine, adenine, cytosine, uracil and thymine; A is a lower alkylamine; and n is any desired natural number, wherein, when n is greater than 1, B', R and R1 in plural numbers may be either identical or different.

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