Nucleotide compounds having a cleavable linker

Details Nucleotide compounds having a cleavable linker Nucleotide compounds having a cleavable linker

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2411514

It has turned out to be valuable to use a disulfide-bonded cleavable nucleotide complex ac- cording formula I Dye - SS - Linker - Nucleotide (formula I) wherein Dye is a fluorophore; SS is a disulfide bridge; Linker is a useful linking group, such as - C .ident. - CH2 - NH - CO - CH2 -; and Nucleotide is a nucleotide chosen from the group of dCTP, dATP, dGTP, dTTP, ri- bonucleotides ar further modified nucleotides; in nucleic acid assay methods.

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