C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/49 (2006.01) A61K 31/70 (2006.01) C07K 14/16 (2006.01)
Patent
CA 2369119
The present invention relates to a method for producing a nucleotide sequence construct with optimized codons for an HIV genetic vaccine based on a primary, early HIV isolate. Specific such nucleotide sequence construct are the synthetic envelope BX08 constructs. The invention further relates to the medical use of such constructs for the treatment and prophylaxis of HIV through DNA vaccine and for diagnostics.
L'invention concerne une méthode de production d'une construction de séquence de nucléotides à base de codons optimisés, pour un vaccin génétique contre le VIH, à partir d'un isolat primaire et précoce du VIH. Cette construction spécifique de séquence de nucléotides est celle de l'enveloppe synthétique BX08. L'invention concerne également l'usage médical de cette construction dans le traitement et la prévention du VIH grâce à des vaccins d'ADN, ainsi qu'à des fins diagnostiques.
Sim & Mcburney
Statens Serum Institut
LandOfFree
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