Nucleotide expression systems with reduced immunogenicity...

Details Nucleotide expression systems with reduced immunogenicity... Nucleotide expression systems with reduced immunogenicity...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/34 (2006.01) C12N 15/38 (2006.01)

Patent

CA 2318664

This invention suppresses the immune response to viral or non-viral based methods of gene delivery by incorporating immunosuppressive genes within the gene delivery system. These immunosuppressive genes may be used in addition to a therapeutic treatment or as a therapeutic treatment by themselves.

La présente invention concerne un procédé permettant la suppression de la réponse immunitaire en cas d'introduction de gènes selon des techniques de type virales ou non virales. A cet effet, on incorpore des gènes d'immuno-dépression dans le système d'introduction des gènes. Ces gènes d'immuno-dépression peuvent s'utiliser en complément d'un traitement thérapeutique ou directement comme traitement thérapeutique.

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