C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/00 (2006.01) C07H 19/10 (2006.01) C07H 19/14 (2006.01) C07H 19/20 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2477741
The present invention relates to nucleoside disphosphate mimics and nucleoside triphosphate mimics, which contain disphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or base-modifications. The nucleotide mimics of the present invention, in a form of a pharmaceutically acceptable salt, a pharmaceutically acceptable prodrug, or a pharmaceutical formulation, are useful as antiviral, antimicrobial, and anticancer agents. The present invention provides a method for the treatment of viral infections, microbial infections, and proliferative disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of the present invention optionally in combination with other pharmaceutically active agents.
La présente invention concerne des mimétiques nucléosidiques du disphosphate et des mimétiques nucléosidiques du trisphosphate, qui contiennent des mimétiques de fragments du disphosphate ou du trisphosphate, et éventuellement des modifications par des sucres et/ou des modifications par des bases. Les mimétiques nucléotidiques de l'invention, qui se présentent sous forme de sel pharmaceutiquement acceptable, de promédicament pharmaceutiquement acceptable ou de formulation pharmaceutique, sont utiles comme agents antiviraux, antimicrobiens ou anticancéreux. L'invention concerne une méthode de traitement d'infections virales, d'infections microbiennes, ou de troubles à évolution chronique. Elle concerne en outre des compositions pharmaceutiques contenant les composés de l'invention associés éventuellement à d'autres agents pharmaceutiquement actifs.
Ariza Maria Eugenia
Boyle Nicholas A.
Brooks Jennifer L.
Bruice Thomas W.
Cook Phillip Dan
Biota Inc.
Biota Scientific Management Pty Ltd
Fetherstonhaugh & Co.
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