Nucleotide or nucleosidephotoaffinity compound modified...

Details Nucleotide or nucleosidephotoaffinity compound modified... Nucleotide or nucleosidephotoaffinity compound modified...

C - Chemistry, Metallurgy

07

K

C07K 1/13 (2006.01) A61K 47/48 (2006.01) C07K 1/107 (2006.01) C07K 16/00 (2006.01) C07K 16/30 (2006.01) C12N 9/96 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/532 (2006.01) G01N 33/533 (2006.01) G01N 33/534 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2183898

Sites on antibodies having affinity for photoaffinity compounds, in particular purine or azidopurine containing compounds are taught. These sites provide for the site-specific attachment of nucleotide photoaffinity compounds to rlntibodies, e.g., ATP- or GTP-analog photoaffinity compounds by photochemical means. These nucleotide photoaffinity compounds may additionally be attached to molocules having a desired therapeutic or diagnostic activity, and the resultant conjugates used as diagnostics or therapeutics.

L'invention se rapporte à des sites sur des anticoprs présentant une affinité pour des composés de photoaffinité, notamment des composés contenant de la purine ou de l'azidopurine. Ces sites assurent la fixation dirigée sur un site de composés de photoaffinité nucléotidiques sur des anticorps, par exemple, des composés de photoaffinité analogues à ATP ou GTP par des moyens photochimiques. Ces composés de photoaffinité nucléotidiques peuvent de plus être fixés à des molécules présentant une activité thérapeutique ou diagnostique désirée, et les conjugués obtenus sont utilisés comme moyens diagnostiques ou thérapeutiques.

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