Nucleotide polymorphisms associated with osteoporosis

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2471376

The invention relates to polynucleotides associated with susceptibility to low bone mineral density and/or bone damage generally associated with human diseases, and in particular to osteoporosis. The invention further relates to polymorphic polynucleotides associated with osteoporosis. The invention provides methods of determining if a particular polymorphism predisposes an individual to or is associated with the development of osteoporosis. The invention also provides methods of detecting the presence of one or more polymorphism as an indicator of osteoporosis, and provides for use of novel polynucleotides of the invention in the development of drugs and in disease treatment.

La présente invention concerne des polynucléotides associés à la susceptibilité à une faible teneur minérale des os et/ou à la dégradation osseuse généralement associée à des maladies humaines telles que, en particulier, l'ostéoporose. L'invention se rapporte également à des polynucléotides polymorphes associés à l'ostéoporose. L'invention se rapporte à des procédés permettant de déterminer si un polymorphisme particulier prédispose un individu au développement de l'ostéoporose ou est associé à ce développement. L'invention se rapporte en outre à des procédés de détection de la présence d'un ou de plusieurs polymorphismes constituant des indicateurs de l'ostéoporose, ainsi qu'à l'utilisation des nouveaux polynucléotides décrits ci-dessus pour le développement de médicaments et le traitement de maladies.

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